Skeletal Muscle is a peer-reviewed, open access, online journal that publishes articles investigating molecular mechanisms underlying the biology of skeletal muscle. A wide range of skeletal muscle biology is included: development, metabolism, the regulation of mass and function, aging, degeneration, dystrophy and regeneration. The emphasis is on understanding adult skeletal muscle, its maintenance, and its interactions with non-muscle cell types and regulatory modulators.
Call for Papers: Gene Therapy in Skeletal Muscle and Neuromuscular Diseases
We are proud to announce a new Collection focusing on gene therapies in skeletal muscle and neuromuscular diseases. We welcome articles exploring various aspects of gene therapy for these diseases, and highlighting measures to overcome the challenges related to gene therapies.
Featured Article: N-terminal titin fragment: a non-invasive, pharmacodynamic biomarker for microdystrophin efficacy
Back to topSkeletal Muscle is excited to feature the recently published paper: "N-terminal titin fragment: a non-invasive, pharmacodynamic biomarker for microdystrophin efficacy" by Solid Biosciences. This work investigates the use of non-invasive markers to assess the efficacy of microdystrophin gene therapy and to supplement traditional outcomes measures. The N-terminal fragment of titin is elevated in DMD biofluids but was reduced in conjunction with microdystrophin expression in the skeletal muscle and localization to the sarcolemma. Further, this reduction in N-terminal titin was sensitive to lower levels of expressed microdystrophin in the skeletal muscle when compared to serum CK. Biomarkers from non-invasive biofluids, like the N-terminal fragment of titin, have the potential to provide additional confidence in drug efficacy, to help drug developers reach decisions faster, and to reduce the burden of clinical trial participation for patients and their families. Image Created with Biorender.
Articles
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Pannexin 1 dysregulation in Duchenne muscular dystrophy and its exacerbation of dystrophic features in mdx mice
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Dimorphic effect of TFE3 in determining mitochondrial and lysosomal content in muscle following denervation
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IL-33-ST2 signaling in fibro-adipogenic progenitors alleviates immobilization-induced muscle atrophy in mice
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Metabolic signatures and potential biomarkers of sarcopenia in suburb-dwelling older Chinese: based on untargeted GC–MS and LC–MS
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The endogenous molecular clock orchestrates the temporal separation of substrate metabolism in skeletal muscle
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Aberrant repair and fibrosis development in skeletal muscle
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Idiopathic inflammatory myopathies: pathogenic mechanisms of muscle weakness
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Regulation of skeletal muscle growth by the IGF1-Akt/PKB pathway: insights from genetic models
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T-tubule biogenesis and triad formation in skeletal muscle and implication in human diseases
Featured blogs
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Investigating the genetics behind muscular dystrophy in dogs
05 September 2017
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Tackling ischemia to treat DMD
01 July 2014
Aims and scope
Editor quotes
Carmen Birchmeier, co-Editor- in-Chief
"Skeletal muscle provides a platform for work on basic mechanisms used during muscle development, regeneration disease and aging. I find the similarities and differences between developing and adult muscle stem cells particularly fascinating."
Markus A Rüegg, co-Editor-in-Chief
"Skeletal Muscle publishes influential mechanistic and methodological papers in the field and has become an important journal for my own research. I hope to further strengthen the journal´s coverage of mechanisms involved in the pathology of neuromuscular diseases."
David Glass, co-Editor-in-Chief
"The goal of the journal is to understand how the skeletal muscle relevant cellular systems work, so that one might be able to improve human health and combat disease.”
Annual Journal Metrics
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2022 Citation Impact
4.9 - 2-year Impact Factor
4.8 - 5-year Impact Factor
1.171 - SNIP (Source Normalized Impact per Paper)
1.530 - SJR (SCImago Journal Rank)2023 Speed
8 days submission to first editorial decision for all manuscripts (Median)
149 days submission to accept (Median)2023 Usage
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